The Wii version of Guitar Hero III: Legends of Rock may be on equal ground when it comes to content, game modes, and even online play, but the Wii version enjoys the most special treatment when it comes to system-specific features, and the symbiotic relationship of Wii remote and guitar is second to none. Vicarious Visions created an excellent Wii port of Neversoft's complete remaking of the franchise, and this verison proves to be the best version of all, mostly because it is the debut of the franchise on a Nintendo console and avoids the pitfalls of comparisons and preconceptions.
| Game Title | Genre | ESRB | Score |
| Barbie as The Island Princess | Adventure | Everyone | 6.0 |
| Bully: Scholarship Edition | Action | Teen | 9.0 |
| Dance Dance Revolution: Hottest Party | Music | Everyone | 7.6 |
| Dancing with the Stars | Music | Everyone | 7.5 |
| Dragon Ball Z: Budokai Tenkaichi 3 | Fighting | Teen | 8.0 |
| Furu Furu Park | Party Game | Everyone 10+ | 3.3 |
| Godzilla: Unleashed | Fighting | Everyone | 6.1 |
| LEGO Star Wars: The Complete Saga | Action | Everyone | 8.5 |
| Luxor: Pharaoh's Challenge | Puzzle | Everyone | 4.8 |
| Manhunt 2 | Action | Mature | 6.0 |
| Mario Kart | Racing | Everyone | 4.2 |
| My Word Coach | Edutainment | Everyone | 7.0 |
| NiGHTS: Journey of Dreams | Action | Everyone | 9.0 |
| Puzzle Quest: Challenge of the Warlords | Puzzle-RPG | Everyone | 8.0 |
| Samurai Warriors Katana | Action | Teen | 3.2 |
| SEGA Bass Fishing | Hunting | Everyone | 6.0 |
| Spiderwick Chronicles, The | Adventure | Everyone 10+ | 5.3 |
| Star Trek: Conquest | Strategy | Everyone | 4.8 |
| Victorious Boxers: Revolution | Sports | Teen | 6.3 |
| Game Title | Date* |
| Boom Blox | 05/06 |
| Speed Racer | 05/06 |
| The Dog Island | 05/06 |
| Final Fantasy Crystal Chronicles: My Life as a King | 05/12 |
| Major League Eating: The Game | 05/12 |
| Toki Tori | 05/12 |
| Castle of Shikigami III | 05/13 |
| Deca Sports | 05/13 |
| We Ski | 05/13 |
| The Chronicles of Narnia: Prince Caspian | 05/15 |
| Blast Works: Build, Trade, Destroy | 05/20 |
| Kawasaki Snow Mobiles | 05/20 |
| Wii Fit | 05/21 |
| Death Jr.: Root of Evil | 05/27 |
| Emergency Heroes | 05/27 |
| Kung Fu Panda | 06/03 |
| Lego Indiana Jones: The Original Adventures | 06/03 |
| The Incredible Hulk | 06/03 |
| Wacky Races: Crash & Dash | 06/03 |
*Release dates are subject to change
| Game Title | Score |
| Carnival Games | 8.3 |
| Guitar Hero III: Legends of Rock | 9.0 |
| NiGHTS: Journey of Dreams | 9.0 |
| Super Paper Mario | 8.7 |